RS1048661 LOXL1
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What This Variant Does
"rs1048661, also known as R141L, a SNP causing an amino acid change in the lysyl oxidase 1 LOXL1 gene...
Associated Conditions
Exfoliation syndrome
susceptibility to
Exfoliation syndrome
susceptibility to
GWAS Studies (9)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Hand grip strength (baseline) | G | β: 0.012 | 2E-15 | PubMed |
| Descending aorta maximum area (MTAG) | G | OR: 4.23 | 7E-14 | PubMed |
| Descending aorta maximum area | G | OR: 4.22 | 1E-13 | PubMed |
| Descending thoracic aortic diameter | G | β: 0.038 | 2E-11 | PubMed |
| Descending thoracic aortic diameter | G | β: 0.039 | 1E-10 | PubMed |
| Descending aorta diameter | G | β: 0.035 | 6E-10 | PubMed |
| Carpal tunnel syndrome | T | OR: 0.96 | 8E-10 | PubMed |
| Descending aorta minimum area | — | OR: 3.86 | 4E-9 | PubMed |
| Descending aorta minimum area | — | OR: 4.7 | 2E-8 | PubMed |
Population Frequencies
gnomAD ALL
0%
1kG AFR
84.6%
1kG ALL
31.1%
1kG AMR
30.5%
1kG EAS
51.8%
1kG EUR
68%
1kG SAS
30.7%
Other Variants in LOXL1