Genetic variant
rs1047891
rs1047891 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1047891 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1047891, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1047891
- Position
- chr2:210675783
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Glycine levels | A | OR 0.55 | 9E-14953 | PubMed |
| Glycine levels | A | OR 0.77 | 3E-13622 | PubMed |
| Glycine levels | C | OR 0.54 | 1E-3580 | PubMed |
| Glycine levels | A | OR 0.34 | 3E-2229 | PubMed |
| Glycine levels | A | OR 0.45 | 3E-1655 | PubMed |
| Glycine levels | A | OR 0.55 | 2E-575 | PubMed |
| Gamma-glutamylglycine levels | A | OR 0.43 | 2E-345 | PubMed |
| N-acetylglycine levels | A | OR 0.43 | 1E-341 | PubMed |
| Glycine levels | A | OR 0.57 | 1E-324 | PubMed |
| Histidine levels | A | OR 0.12 | 1E-321 | PubMed |
| Metabolite levels (glycine) | A | OR 0.53 | 5E-303 | PubMed |
| Glycine levels | A | OR 0.57 | 1E-300 | PubMed |
| Glycine levels | A | OR 0.49 | 1E-300 | PubMed |
| Glycine levels | A | OR 0.43 | 1E-300 | PubMed |
| Histidine levels | A | β 0.08 | 6E-287 | PubMed |
| Propionylglycine levels | A | OR 0.4 | 2E-273 | PubMed |
| Red meat related metabolomic signature | A | OR 0.16 | 6E-262 | PubMed |
| Glycine levels | A | OR 0.5 | 3E-222 | PubMed |
| Gamma-glutamylglycine levels | A | OR 0.48 | 5E-216 | PubMed |
| Glycine levels (UKB data field 23462) | A | OR 0.54 | 1E-200 | PubMed |
Sources
- dbSNP: rs1047891 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies