Genetic variant
rs10468017
rs10468017 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10468017 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
T allele is associated with 1.76mg/dl increase in HDL cholesterol (good cholesterol). [GWAS:HDL cho...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10468017, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10468017
- Position
- chr15:58386313
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Triglycerides in very small VLDL | T | OR 0.21 | 6E-875 | PubMed |
| Triglycerides in very small VLDL | T | OR 0.18 | 1E-777 | PubMed |
| Phospholipids in very small VLDL | T | OR 0.19 | 3E-707 | PubMed |
| Total lipids in very small VLDL | T | OR 0.19 | 2E-674 | PubMed |
| Phospholipids in very small VLDL | T | OR 0.17 | 7E-630 | PubMed |
| HDL cholesterol levels | T | β 0.1 | 1E-626 | PubMed |
| Concentration of very small VLDL particles | T | OR 0.18 | 6E-606 | PubMed |
| Total lipids in very small VLDL | T | OR 0.16 | 4E-598 | PubMed |
| Concentration of very small VLDL particles | T | OR 0.15 | 4E-523 | PubMed |
| Phospholipids to Total Lipids in Large VLDL percentage | T | OR 0.15 | 4E-478 | PubMed |
| Cholesteryl Esters in HDL | T | β 0.09 | 7E-442 | PubMed |
| Free cholesterol levels in HDL | C | OR 0.15 | 1E-324 | PubMed |
| high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) | C | OR 0.14 | 1E-323 | PubMed |
| Cholesterol in Medium HDL | T | β 0.08 | 2E-318 | PubMed |
| Phospholipids to Total Lipids in Chylomicrons and Extremely Large VLDL percentage | T | OR 0.12 | 7E-296 | PubMed |
| Cholesterol levels in very large HDL | C | OR 0.15 | 1E-285 | PubMed |
| Cholesteryl ester levels in very large HDL | C | OR 0.15 | 7E-284 | PubMed |
| Cholesterol levels in large HDL | C | OR 0.14 | 1E-278 | PubMed |
| Free cholesterol to total lipids ratio in large HDL | C | OR 0.15 | 1E-275 | PubMed |
| Cholesteryl ester levels in large HDL | C | OR 0.13 | 3E-248 | PubMed |
Sources
- dbSNP: rs10468017 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies