RS1042522 TP53
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What This Variant Does
"This SNP, a variant in the TP53 gene, is 1 of 25 SNPs reported to represent independently minor, but...
Associated Conditions
Li-Fraumeni syndrome
Hereditary cancer-predisposing syndrome
Li-Fraumeni syndrome
Hereditary cancer-predisposing syndrome
GWAS Studies (11)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Sex hormone-binding globulin levels | C | OR: 0.19 | 3E-938 | PubMed |
| Testosterone levels | C | β: 0.066 | 1E-117 | PubMed |
| Glycated hemoglobin levels | C | β: 0.024 | 3E-18 | PubMed |
| TP53 protein levels | C | β: 0.058 | 6E-16 | PubMed |
| Serum total protein levels | C | β: 0.019 | 3E-11 | PubMed |
| Apolipoprotein B levels | C | β: 0.018 | 9E-11 | PubMed |
| Low density lipoprotein cholesterol levels | C | β: 0.018 | 1E-10 | PubMed |
| Non-albumin protein levels | C | β: 0.018 | 4E-10 | PubMed |
| Triglyceride levels | C | β: 0.017 | 4E-10 | PubMed |
| SHBG protein levels | — | OR: 0.21 | 7E-9 | PubMed |
| Body surface area | — | β: 0.003 | 1E-8 | PubMed |
Population Frequencies
gnomAD ALL
0%
1kG AFR
66.9%
1kG ALL
45.7%
1kG AMR
31.7%
1kG EAS
41.4%
1kG EUR
28.5%
1kG SAS
50.8%
Other Variants in TP53