Genetic variant
rs10423928
rs10423928 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10423928 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
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From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10423928, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10423928
- Position
- chr19:45679046
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Body mass index | — | — | 1E-44 | PubMed |
| Body mass index | — | — | 4E-43 | PubMed |
| Body mass index | T | β 0.033 | 3E-42 | PubMed |
| Body mass index (UKB data field 21001) | A | β 0.029 | 3E-37 | PubMed |
| Body mass index | — | β 0.032 | 9E-35 | PubMed |
| Adult body size | T | β 0.021 | 4E-33 | PubMed |
| Weight (UKB data field 21002) | A | β 0.024 | 4E-32 | PubMed |
| Trunk fat mass (UKB data field 23128) | A | β 0.027 | 3E-30 | PubMed |
| Body mass index | A | β 0.035 | 6E-30 | PubMed |
| Waist circumference (UKB data field 48) | A | β 0.023 | 3E-28 | PubMed |
| Whole body fat mass (UKB data field 23100) | A | β 0.032 | 3E-26 | PubMed |
| Predicted visceral adipose tissue | A | β 0.033 | 1E-25 | PubMed |
| Linoleic acid to total fatty acids percentage | A | — | 8E-21 | PubMed |
| Hip circumference (UKB data field 49) | A | β 0.022 | 1E-20 | PubMed |
| Basal metabolic rate (UKB data field 23105) | A | β 0.013 | 5E-20 | PubMed |
| Body surface area | — | β 0.004 | 1E-17 | PubMed |
| Pulse pressure | A | OR 0.17 | 6E-16 | PubMed |
| Omega-6 fatty acids to total fatty acids percentage | A | — | 2E-15 | PubMed |
| Whole body water mass (UKB data field 23102) | A | β 0.011 | 7E-15 | PubMed |
| Obesity | T | OR 1.16 | 4E-13 | PubMed |
Sources
- dbSNP: rs10423928 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies