Genetic variant

rs102275

rs102275 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs102275 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

Common variants at 30 loci contribute to polygenic dyslipidemia. Genome-wide association analysis of...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs102275, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs102275
Position
chr11:61790331

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6) levels C OR 0.61 2E-375 PubMed
Cholesteryl Esters to Total Lipids in Very Small VLDL percentage C β 0.08 4E-375 PubMed
Free Cholesterol to Total Lipids in Large HDL percentage C OR 0.12 3E-355 PubMed
Triglycerides to Total Lipids in IDL percentage C β 0.08 2E-333 PubMed
1-arachidonoyl-gpc (20:4n6) levels C OR 0.56 4E-311 PubMed
1-stearoyl-2-arachidonoyl-GPC (18:0/20:4) levels C OR 0.57 1E-309 PubMed
Cholesterol to Total Lipids in Medium LDL percentage C β 0.08 3E-289 PubMed
Free Cholesterol to Total Lipids in Small VLDL percentage C β 0.07 1E-288 PubMed
Lysophosphatidylethanolamine_22:4_[M-H]1- levels C OR 0.35 2E-286 PubMed
Metabolite levels — — 4E-264 PubMed
Phospholipids to Total Lipids in Small VLDL percentage C β 0.07 6E-264 PubMed
Cholesterol to Total Lipids in Large LDL percentage C β 0.07 9E-264 PubMed
Lysophosphatidylcholine_20:4_[M+H]1+ levels C OR 0.41 2E-263 PubMed
Triglycerides to Total Lipids in Large LDL percentage C β 0.07 5E-258 PubMed
Triglycerides to Total Lipids in Medium VLDL percentage C β 0.07 5E-254 PubMed
Polyunsaturated fatty acid levels C — 1E-236 PubMed
Triglycerides to Total Lipids in Medium LDL percentage C β 0.07 2E-234 PubMed
Phosphatidylcholine (18:0_20:4) levels C OR 0.68 2E-224 PubMed
1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4) levels C OR 0.48 6E-214 PubMed
Polyunsaturated fatty acids to total fatty acids percentage C — 8E-206 PubMed

Sources