Genetic variant
rs10224002
rs10224002 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10224002 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10224002, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10224002
- Position
- chr7:151717955
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Estimated glomerular filtration rate | — | — | 8E-233 | PubMed |
| Creatinine levels | — | — | 2E-156 | PubMed |
| Estimated glomerular filtration rate (creatinine) | G | β 0.008 | 4E-142 | PubMed |
| Estimated glomerular filtration rate | A | β 0.007 | 7E-118 | PubMed |
| Hemoglobin concentration | G | β 0.058 | 5E-58 | PubMed |
| Hemoglobin concentration | G | β 0.062 | 5E-52 | PubMed |
| Creatinine levels | A | β 0.052 | 2E-40 | PubMed |
| Systolic blood pressure | A | OR 0.34 | 1E-15 | PubMed |
| Hemoglobin | G | β 0.07 | 3E-15 | PubMed |
| Hematocrit | G | OR 0.2 | 6E-15 | PubMed |
| SORCS2 protein levels | G | β 0.038 | 8E-12 | PubMed |
| Diastolic blood pressure | A | OR 0.17 | 2E-11 | PubMed |
| Gout | G | OR 1.14 | 4E-10 | PubMed |
| Pulse pressure | A | OR 0.17 | 4E-9 | PubMed |
| Glomerular filtration rate in diabetes | A | OR 2.01 | 3E-8 | PubMed |
| Systolic blood pressure | A | β 0.019 | 3E-7 | PubMed |
| Systolic blood pressure | A | OR 0.31 | 4E-7 | PubMed |
| Glomerular filtration rate in type 2 diabetes | — | OR 2.13 | 8E-7 | PubMed |
Sources
- dbSNP: rs10224002 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies