Genetic variant

rs10127775

rs10127775 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10127775 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10127775, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs10127775
Position
chr1:230160042

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
High density lipoprotein cholesterol levels T β 0.051 1E-170 PubMed
Total lipids in very large VLDL T β 0.04 2E-80 PubMed
Triglycerides in VLDL T β 0.04 1E-79 PubMed
Phospholipid levels in chylomicrons and extremely large VLDL T β 0.04 5E-75 PubMed
Triglyceride levels — β 0.048 6E-73 PubMed
Cholesteryl ester levels in chylomicrons and extremely large VLDL T β 0.04 2E-72 PubMed
Total triglycerides levels T β 0.04 9E-72 PubMed
Triglycerides in medium VLDL T β 0.04 9E-72 PubMed
Cholesterol levels in chylomicrons and extremely large VLDL T β 0.04 3E-71 PubMed
Concentration of chylomicrons and extremely large VLDL particles T β 0.04 4E-70 PubMed
LRIG1 protein levels T β 0.081 8E-68 PubMed
Free cholesterol levels in chylomicrons and extremely large VLDL T β 0.03 1E-66 PubMed
Total lipid levels in chylomicrons and extremely large VLDL T β 0.03 5E-62 PubMed
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) T — 1E-58 PubMed
Triglyceride levels in chylomicrons and extremely large VLDL T β 0.03 8E-54 PubMed
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) T — 6E-48 PubMed
Red blood cell erythrocyte distribution width (UKB data field 30070) T β 0.028 3E-45 PubMed
Platelet count T β 0.027 2E-32 PubMed
Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) T — 9E-31 PubMed
Apolipoprotein B levels A β 0.023 6E-28 PubMed

Sources