Genetic variant
rs10119
rs10119 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10119 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10119, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10119
- Position
- chr19:44903416
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Family history of Alzheimer's disease | — | OR 1.44 | 1E-307 | PubMed |
| Alzheimer's disease | A | — | 2E-161 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | A | — | 4E-131 | PubMed |
| Memory decline | — | β 0.018 | 1E-60 | PubMed |
| Baseline memory | — | OR 0.15 | 3E-59 | PubMed |
| Memory decline | — | β 0.016 | 3E-58 | PubMed |
| Late-onset Alzheimer's disease | — | OR 2.73 | 2E-57 | PubMed |
| Baseline memory | — | OR 0.14 | 5E-56 | PubMed |
| Memory decline | — | β 0.017 | 1E-50 | PubMed |
| Memory decline | — | β 0.017 | 2E-48 | PubMed |
| Baseline memory | — | OR 0.14 | 6E-44 | PubMed |
| Baseline memory | — | OR 0.13 | 9E-43 | PubMed |
| Memory decline in impaired cognition | — | β 0.029 | 3E-38 | PubMed |
| Baseline memory in impaired cognition | — | OR 0.21 | 1E-30 | PubMed |
| Baseline memory in impaired cognition | — | OR 0.16 | 2E-25 | PubMed |
| Multi-trait sum score | — | — | 3E-22 | PubMed |
| Vascular dementia | G | OR 0.33 | 1E-17 | PubMed |
| Multi-trait sum score | — | — | 4E-14 | PubMed |
| Memory decline in normal cognition | — | β 0.008 | 4E-14 | PubMed |
| Memory decline in normal cognition | — | β 0.008 | 4E-14 | PubMed |
Sources
- dbSNP: rs10119 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies