Genetic variant
rs10069690
rs10069690 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10069690 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10069690, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10069690
- Position
- chr5:1279675
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Glioblastoma | T | OR 1.61 | 8E-74 | PubMed |
| Glioma | T | OR 1.45 | 3E-66 | PubMed |
| Uterine fibroids | T | β 0.099 | 3E-48 | PubMed |
| Uterine fibroids | T | OR 0.11 | 7E-44 | PubMed |
| Uterine leiomyoma or breast cancer (pleiotropy) | T | — | 2E-42 | PubMed |
| Uterine fibroids | — | — | 8E-42 | PubMed |
| ICD10 D25: Leiomyoma of uterus | C | OR 0.9 | 4E-38 | PubMed |
| Breast cancer (estrogen-receptor negative) | T | OR 1.18 | 2E-35 | PubMed |
| Glioblastoma | T | OR 1.64 | 3E-35 | PubMed |
| Uterine leiomyomata | T | OR 1.12 | 2E-34 | PubMed |
| Uterine fibroids | T | OR 0.12 | 2E-34 | PubMed |
| Glioblastoma (age-stratified) | T | OR 1.78 | 4E-33 | PubMed |
| Non-albumin protein levels | T | β 0.033 | 4E-31 | PubMed |
| Breast cancer (estrogen-receptor negative) | T | OR 1.3 | 3E-24 | PubMed |
| Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) | T | OR 1.38 | 1E-23 | PubMed |
| Breast cancer or ovarian cancer (pleiotropy) | C | — | 5E-23 | PubMed |
| Systolic blood pressure | T | OR 0.28 | 4E-22 | PubMed |
| Benign nodular goiter | T | β 0.069 | 3E-21 | PubMed |
| Lipoma (PheCode 214) | C | OR 0.1 | 4E-21 | PubMed |
| Systolic blood pressure | T | OR 0.27 | 4E-21 | PubMed |
Sources
- dbSNP: rs10069690 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies