Genetic variant
rs10058074
rs10058074 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10058074 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10058074, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10058074
- Position
- chr5:132350453
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Height | A | β 0.036 | 1E-300 | PubMed |
| White blood cell count | A | — | 4E-71 | PubMed |
| Platelet forward scatter | A | β 0.072 | 3E-19 | PubMed |
| Platelet count | A | β 0.032 | 3E-18 | PubMed |
| MTIF3 protein levels | A | β 0.049 | 2E-16 | PubMed |
| ACOT13 protein levels | A | β 0.048 | 7E-16 | PubMed |
| CHMP6 protein levels | A | β 0.046 | 5E-15 | PubMed |
| SLC9A3R1 protein levels | A | β 0.045 | 4E-14 | PubMed |
| EDF1 protein levels | A | β 0.045 | 3E-13 | PubMed |
| YWHAQ protein levels | A | β 0.042 | 2E-12 | PubMed |
| NT5C protein levels | A | β 0.037 | 2E-12 | PubMed |
| IST1 protein levels | A | β 0.043 | 2E-12 | PubMed |
| HHEX protein levels | A | β 0.041 | 2E-12 | PubMed |
| ITPR1 protein levels | A | β 0.04 | 3E-12 | PubMed |
| LPP protein levels | A | β 0.043 | 3E-12 | PubMed |
| Height | A | OR 1.15 | 4E-12 | PubMed |
| VASP protein levels | A | β 0.041 | 1E-11 | PubMed |
| PGD protein levels | A | β 0.039 | 2E-11 | PubMed |
| RAB10 protein levels | A | β 0.041 | 2E-11 | PubMed |
| X-11381 levels | A | β 0.096 | 3E-11 | PubMed |
Sources
- dbSNP: rs10058074 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies