Genetic variant
rs10048146
rs10048146 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10048146 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10048146, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10048146
- Position
- chr16:86677054
Genome-wide association studies (17)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Height | G | β 0.014 | 2E-74 | PubMed |
| Vertex-wise sulcal depth | G | OR 14.07 | 6E-45 | PubMed |
| Vertex-wise cortical surface area | G | OR 9.33 | 1E-20 | PubMed |
| Cortical surface area | G | — | 1E-17 | PubMed |
| Femoral neck bone mineral density | A | β 0.05 | 1E-14 | PubMed |
| Number of decayed, missing and filled tooth surfaces or use of dentures | A | β 0.026 | 5E-14 | PubMed |
| Dentures | A | β 0.051 | 4E-13 | PubMed |
| Dental caries | G | OR 6.89 | 6E-12 | PubMed |
| Cortical surface area (MOSTest) | — | — | 8E-12 | PubMed |
| Bone mineral density (femoral neck) | — | — | 1E-11 | PubMed |
| Brain morphology (MOSTest) | — | — | 5E-11 | PubMed |
| Bone mineral density (spine) | — | — | 7E-10 | PubMed |
| Bone mineral density (femoral neck) | — | — | 8E-9 | PubMed |
| IDP T1 FAST ROIs R planum temporale | G | β 0.069 | 1E-8 | PubMed |
| Bone mineral density (spine) | G | β 0.09 | 2E-8 | PubMed |
| Bone mineral density (hip) | G | β 0.09 | 2E-7 | PubMed |
| T1 CAT volume L MiddleTemporalGyrusanteriordivision | G | β 0.067 | 2E-6 | PubMed |
Sources
- dbSNP: rs10048146 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies