XRCC2 Chromosome 7
X-ray repair cross complementing 2
Upload your DNA to see your personal genotypes for variants in XRCC2.
What This Gene Does
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"FA complementation groups|RAD51 paralogs"
Locus Type
gene with protein product
Location
7q36.1
Ensembl
ENSG00000196584
Associated Conditions (15)
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group U
XRCC2-related disorder
Spermatogenic failure 50
Premature ovarian failure 17
Ovarian serous cystadenocarcinoma
Short stature
microcephaly
and endocrine dysfunction
Hereditary breast ovarian cancer syndrome
Colorectal cancer
Familial prostate cancer
Colon cancer
Breast carcinoma
Malignant tumor of unknown origin
Key Variants
RS1064794505
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1213272601
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1327414828
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS140214637
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group U, XRCC2-related disorder
Health Risk
RS143153871
Conflicting classifications of pathogenicity
Fanconi anemia complementation group U, Hereditary cancer-predisposing syndrome, Short stature
Health Risk
RS1454417236
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS149099078
Conflicting classifications of pathogenicity
Fanconi anemia complementation group U, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group U
Health Risk
RS149186933
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Spermatogenic failure 50, Premature ovarian failure 17
Health Risk
RS149929851
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS151110146
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Spermatogenic failure 50, Premature ovarian failure 17
Health Risk
RS1554411684
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1554413532
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
All Variants (62)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1064794088 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1590129487 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS201836415 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2098027525 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2485880908 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2485881210 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2485881405 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2485881817 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2485882087 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2485915620 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS764640893 | Health Risk | Likely pathogenic | Fanconi anemia complementation group U, Hereditary cancer-predisposing syndrome, Spermatogenic failure 50 |
| RS2485881992 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |