XIRP2 Chromosome 2
Xin actin binding repeat containing 2
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What This Gene Does
Enables actin filament binding activity. Predicted to be involved in actin filament organization and regulation of actin filament organization. Predicted to act upstream of or within cardiac muscle tissue morphogenesis; cell-cell junction organization; and ventricular septum development. Located in focal adhesion and stress fiber. Implicated in depressive disorder. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
LIM domain containing
Locus Type
gene with protein product
Location
2q24.3
Ensembl
ENSG00000163092
Associated Conditions (1)
XIRP2-related disorder
Key Variants
RS1226462938
Conflicting classifications of pathogenicity
Health Risk
RS138376962
Conflicting classifications of pathogenicity
Health Risk
RS141843026
Conflicting classifications of pathogenicity
XIRP2-related disorder, XIRP2-related disorder
Health Risk
RS144071626
Conflicting classifications of pathogenicity
Health Risk
RS151314564
Conflicting classifications of pathogenicity
XIRP2-related disorder, XIRP2-related disorder
Health Risk
RS185796429
Conflicting classifications of pathogenicity
Health Risk
RS189318877
Conflicting classifications of pathogenicity
Health Risk
RS190407445
Conflicting classifications of pathogenicity
Health Risk
RS199799734
Conflicting classifications of pathogenicity
Health Risk
RS200243805
Conflicting classifications of pathogenicity
Health Risk
RS200824426
Conflicting classifications of pathogenicity
Health Risk
RS202045863
Conflicting classifications of pathogenicity
Health Risk
All Variants (16)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1226462938 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS138376962 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS141843026 | Health Risk | Conflicting classifications of pathogenicity | XIRP2-related disorder, XIRP2-related disorder |
| RS144071626 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS151314564 | Health Risk | Conflicting classifications of pathogenicity | XIRP2-related disorder, XIRP2-related disorder |
| RS185796429 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS189318877 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS190407445 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS199799734 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS200243805 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS200824426 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS202045863 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS202167735 | Health Risk | Conflicting classifications of pathogenicity | XIRP2-related disorder, XIRP2-related disorder |
| RS372135000 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS752276378 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS773766107 | Health Risk | Conflicting classifications of pathogenicity | — |