WNT9B Chromosome 17
Wnt family member 9B
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What This Gene Does
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Info
Gene Group
Wnt family
Locus Type
gene with protein product
Location
17q21.32
Ensembl
ENSG00000158955
Associated Conditions (5)
Inborn genetic diseases
Renal dysplasia
Chronic kidney disease
Renal hypoplasia
Cystic renal dysplasia
Key Variants
RS142604963
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS1291189006
Likely pathogenic
Renal dysplasia, Chronic kidney disease, Renal hypoplasia
Health Risk
RS753748759
Likely pathogenic
Cystic renal dysplasia, Chronic kidney disease, Cystic renal dysplasia
Health Risk
All Variants (3)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS142604963 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS1291189006 | Health Risk | Likely pathogenic | Renal dysplasia, Chronic kidney disease, Renal hypoplasia |
| RS753748759 | Health Risk | Likely pathogenic | Cystic renal dysplasia, Chronic kidney disease, Cystic renal dysplasia |