WEE2 Chromosome 7
WEE2 oocyte meiosis inhibiting kinase
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What This Gene Does
Predicted to enable protein tyrosine kinase activity. Predicted to be involved in several processes, including female pronucleus assembly; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of meiotic cell cycle. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (2)
WEE2-related disorder
Oocyte maturation defect 5
Key Variants
RS45535636
Conflicting classifications of pathogenicity
WEE2-related disorder, WEE2-related disorder
Health Risk
RS768323979
Likely pathogenic
Oocyte maturation defect 5, WEE2-related disorder, Oocyte maturation defect 5
Health Risk
RS1380657460
Pathogenic
Oocyte maturation defect 5, Oocyte maturation defect 5
Health Risk
RS1554415096
Pathogenic
Oocyte maturation defect 5, Oocyte maturation defect 5
Health Risk
RS1554416415
Pathogenic
Oocyte maturation defect 5, Oocyte maturation defect 5
Health Risk
RS2485617639
Pathogenic
Health Risk
RS754062320
Pathogenic
Oocyte maturation defect 5, Oocyte maturation defect 5
Health Risk
RS905047580
Pathogenic
Oocyte maturation defect 5, Oocyte maturation defect 5
Health Risk
All Variants (8)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS45535636 | Health Risk | Conflicting classifications of pathogenicity | WEE2-related disorder, WEE2-related disorder |
| RS768323979 | Health Risk | Likely pathogenic | Oocyte maturation defect 5, WEE2-related disorder, Oocyte maturation defect 5 |
| RS1380657460 | Health Risk | Pathogenic | Oocyte maturation defect 5, Oocyte maturation defect 5 |
| RS1554415096 | Health Risk | Pathogenic | Oocyte maturation defect 5, Oocyte maturation defect 5 |
| RS1554416415 | Health Risk | Pathogenic | Oocyte maturation defect 5, Oocyte maturation defect 5 |
| RS2485617639 | Health Risk | Pathogenic | — |
| RS754062320 | Health Risk | Pathogenic | Oocyte maturation defect 5, Oocyte maturation defect 5 |
| RS905047580 | Health Risk | Pathogenic | Oocyte maturation defect 5, Oocyte maturation defect 5 |