UIMC1 Chromosome 5
Ubiquitin interaction motif containing 1
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What This Gene Does
This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Info
Gene Group
"BRCA1 A complex|Zinc fingers UBZ4 CCHC-type"
Locus Type
gene with protein product
Location
5q35.2
Ensembl
ENSG00000087206
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS766633588 | Health Risk | Likely pathogenic | — |