UGT2B7 Chromosome 4

UDP glucuronosyltransferase family 2 member B7

127 variants 127 Drug Response

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What This Gene Does

The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]

Gene Info

Gene Group

UDP glucuronosyltransferases

Locus Type

gene with protein product

Location

4q13.2

Ensembl

ENSG00000171234

Associated Conditions (1)

Tramadol response

Key Variants

RS1048277645

drug response

Tramadol response, Tramadol response

Drug Response

RS1157290351

drug response

Tramadol response, Tramadol response

Drug Response

RS1198796766

drug response

Tramadol response, Tramadol response

Drug Response

RS12233719

drug response

Tramadol response, Tramadol response

Drug Response

RS1255338508

drug response

Tramadol response, Tramadol response

Drug Response

RS1259514034

drug response

Tramadol response, Tramadol response

Drug Response

RS12647681

drug response

Tramadol response, Tramadol response

Drug Response

RS12647682

drug response

Tramadol response, Tramadol response

Drug Response

RS12648462

drug response

Tramadol response, Tramadol response

Drug Response

RS1272501790

drug response

Tramadol response, Tramadol response

Drug Response

RS1291339023

drug response

Tramadol response, Tramadol response

Drug Response

RS1300063360

drug response

Tramadol response, Tramadol response

Drug Response

All Variants (127)

RSID	Category	Clinical Significance	Conditions
RS1577921622	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921626	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921638	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921669	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921738	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921765	Drug Response	drug response	Tramadol response, Tramadol response
RS1577922078	Drug Response	drug response	Tramadol response, Tramadol response
RS1577922194	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924333	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924336	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924539	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924566	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924575	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924605	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924620	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924627	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924631	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924635	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924652	Drug Response	drug response	Tramadol response, Tramadol response
RS1577924674	Drug Response	drug response	Tramadol response, Tramadol response
RS1577926868	Drug Response	drug response	Tramadol response, Tramadol response
RS1577926872	Drug Response	drug response	Tramadol response, Tramadol response
RS1577926905	Drug Response	drug response	Tramadol response, Tramadol response
RS1577926907	Drug Response	drug response	Tramadol response, Tramadol response
RS1577927619	Drug Response	drug response	Tramadol response, Tramadol response
RS1577927627	Drug Response	drug response	Tramadol response, Tramadol response
RS1577927645	Drug Response	drug response	Tramadol response, Tramadol response
RS1577927789	Drug Response	drug response	Tramadol response, Tramadol response
RS1577927792	Drug Response	drug response	Tramadol response, Tramadol response
RS1577927873	Drug Response	drug response	Tramadol response, Tramadol response
RS1577927899	Drug Response	drug response	Tramadol response, Tramadol response
RS1577927913	Drug Response	drug response	Tramadol response, Tramadol response
RS1577929997	Drug Response	drug response	Tramadol response, Tramadol response
RS1577930172	Drug Response	drug response	Tramadol response, Tramadol response
RS1577930188	Drug Response	drug response	Tramadol response, Tramadol response
RS1577930208	Drug Response	drug response	Tramadol response, Tramadol response
RS1577930218	Drug Response	drug response	Tramadol response, Tramadol response
RS1577930327	Drug Response	drug response	Tramadol response, Tramadol response
RS1577930454	Drug Response	drug response	Tramadol response, Tramadol response
RS1577930519	Drug Response	drug response	Tramadol response, Tramadol response
RS28365062	Drug Response	drug response	Tramadol response, Tramadol response
RS28365063	Drug Response	drug response	Tramadol response, Tramadol response
RS34661811	Drug Response	drug response	Tramadol response, Tramadol response
RS373107309	Drug Response	drug response	Tramadol response, Tramadol response
RS373954369	Drug Response	drug response	Tramadol response, Tramadol response
RS4292394	Drug Response	drug response	Tramadol response, Tramadol response
RS4337789	Drug Response	drug response	Tramadol response, Tramadol response
RS563256432	Drug Response	drug response	Tramadol response, Tramadol response
RS57913007	Drug Response	drug response	Tramadol response, Tramadol response
RS60529914	Drug Response	drug response	Tramadol response, Tramadol response

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