UGT2B7 Chromosome 4

UDP glucuronosyltransferase family 2 member B7

127 variants 127 Drug Response

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What This Gene Does

The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]

Gene Info

Gene Group

UDP glucuronosyltransferases

Locus Type

gene with protein product

Location

4q13.2

Ensembl

ENSG00000171234

Associated Conditions (1)

Tramadol response

Key Variants

RS1048277645

drug response

Tramadol response, Tramadol response

Drug Response

RS1157290351

drug response

Tramadol response, Tramadol response

Drug Response

RS1198796766

drug response

Tramadol response, Tramadol response

Drug Response

RS12233719

drug response

Tramadol response, Tramadol response

Drug Response

RS1255338508

drug response

Tramadol response, Tramadol response

Drug Response

RS1259514034

drug response

Tramadol response, Tramadol response

Drug Response

RS12647681

drug response

Tramadol response, Tramadol response

Drug Response

RS12647682

drug response

Tramadol response, Tramadol response

Drug Response

RS12648462

drug response

Tramadol response, Tramadol response

Drug Response

RS1272501790

drug response

Tramadol response, Tramadol response

Drug Response

RS1291339023

drug response

Tramadol response, Tramadol response

Drug Response

RS1300063360

drug response

Tramadol response, Tramadol response

Drug Response

All Variants (127)

RSID	Category	Clinical Significance	Conditions
RS1048277645	Drug Response	drug response	Tramadol response, Tramadol response
RS1157290351	Drug Response	drug response	Tramadol response, Tramadol response
RS1198796766	Drug Response	drug response	Tramadol response, Tramadol response
RS12233719	Drug Response	drug response	Tramadol response, Tramadol response
RS1255338508	Drug Response	drug response	Tramadol response, Tramadol response
RS1259514034	Drug Response	drug response	Tramadol response, Tramadol response
RS12647681	Drug Response	drug response	Tramadol response, Tramadol response
RS12647682	Drug Response	drug response	Tramadol response, Tramadol response
RS12648462	Drug Response	drug response	Tramadol response, Tramadol response
RS1272501790	Drug Response	drug response	Tramadol response, Tramadol response
RS1291339023	Drug Response	drug response	Tramadol response, Tramadol response
RS1300063360	Drug Response	drug response	Tramadol response, Tramadol response
RS1314742807	Drug Response	drug response	Tramadol response, Tramadol response
RS1327715763	Drug Response	drug response	Tramadol response, Tramadol response
RS1344464876	Drug Response	drug response	Tramadol response, Tramadol response
RS1369776133	Drug Response	drug response	Tramadol response, Tramadol response
RS1386213886	Drug Response	drug response	Tramadol response, Tramadol response
RS1395641165	Drug Response	drug response	Tramadol response, Tramadol response
RS1403703291	Drug Response	drug response	Tramadol response, Tramadol response
RS1412192907	Drug Response	drug response	Tramadol response, Tramadol response
RS1423616754	Drug Response	drug response	Tramadol response, Tramadol response
RS1424717351	Drug Response	drug response	Tramadol response, Tramadol response
RS1436844953	Drug Response	drug response	Tramadol response, Tramadol response
RS1458035928	Drug Response	drug response	Tramadol response, Tramadol response
RS147120761	Drug Response	drug response	Tramadol response, Tramadol response
RS1479676448	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920581	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920582	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920587	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920640	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920642	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920696	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920737	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920742	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920799	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920813	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920819	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920928	Drug Response	drug response	Tramadol response, Tramadol response
RS1577920993	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921077	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921091	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921116	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921125	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921167	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921281	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921336	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921353	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921432	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921469	Drug Response	drug response	Tramadol response, Tramadol response
RS1577921483	Drug Response	drug response	Tramadol response, Tramadol response

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