TRIM28 Chromosome 19
Tripartite motif containing 28
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What This Gene Does
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"Ring finger proteins|Tripartite motif family|PHD finger proteins|Protein phosphatase 1 regulatory subunits|Bromodomain containing|MicroRNA protein coding host genes"
Locus Type
gene with protein product
Location
19q13.43
Ensembl
ENSG00000130726
Associated Conditions (2)
Nephroblastoma
Predisposition to Wilms tumor
Key Variants
All Variants (3)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS145844294 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS2053798835 | Health Risk | Pathogenic | Nephroblastoma, Nephroblastoma |
| RS2122629233 | Health Risk | Pathogenic | Predisposition to Wilms tumor, Predisposition to Wilms tumor |