TNIP1 Chromosome 5
TNFAIP3 interacting protein 1
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What This Gene Does
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Associated Conditions (1)
Amyotrophic lateral sclerosis
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2233289 | Health Risk | Conflicting classifications of pathogenicity | Amyotrophic lateral sclerosis, Amyotrophic lateral sclerosis |