TIMELESS Chromosome 12

Timeless circadian regulator

2 variants 2 Health Risk

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What This Gene Does

The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]

Associated Conditions (3)

Advance sleep phase syndrome

familial

Key Variants

RS765995979

Conflicting classifications of pathogenicity

Advance sleep phase syndrome, familial, 4

Health Risk

RS1465092391

Pathogenic

Advance sleep phase syndrome, familial, 4

Health Risk

All Variants (2)

RSID	Category	Clinical Significance	Conditions
RS765995979	Health Risk	Conflicting classifications of pathogenicity	Advance sleep phase syndrome, familial, 4
RS1465092391	Health Risk	Pathogenic	Advance sleep phase syndrome, familial, 4