SLC27A5 Chromosome 19
Solute carrier family 27 member 5
Upload your DNA to see your personal genotypes for variants in SLC27A5.
What This Gene Does
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"Acyl-CoA synthetase family|Solute carrier family 27"
Locus Type
gene with protein product
Location
19q13.43
Ensembl
ENSG00000083807
Associated Conditions (9)
SLC27A5-related disorder
Uveal melanoma
Lung cancer
Familial cancer of breast
Cervical cancer
Sarcoma
Gastric cancer
Ovarian serous cystadenocarcinoma
Malignant tumor of esophagus
Key Variants
RS1162988139
Conflicting classifications of pathogenicity
Health Risk
RS141574728
Conflicting classifications of pathogenicity
SLC27A5-related disorder, SLC27A5-related disorder
Health Risk
RS143272701
Conflicting classifications of pathogenicity
SLC27A5-related disorder, SLC27A5-related disorder
Health Risk
RS146267408
Conflicting classifications of pathogenicity
SLC27A5-related disorder, SLC27A5-related disorder
Health Risk
RS146415600
Conflicting classifications of pathogenicity
SLC27A5-related disorder, SLC27A5-related disorder
Health Risk
RS146682651
Conflicting classifications of pathogenicity
SLC27A5-related disorder, SLC27A5-related disorder
Health Risk
RS147464959
Conflicting classifications of pathogenicity
SLC27A5-related disorder, SLC27A5-related disorder
Health Risk
RS148459550
Conflicting classifications of pathogenicity
SLC27A5-related disorder, SLC27A5-related disorder
Health Risk
RS149541658
Conflicting classifications of pathogenicity
Health Risk
RS149709084
Conflicting classifications of pathogenicity
SLC27A5-related disorder, SLC27A5-related disorder
Health Risk
RS150780205
Conflicting classifications of pathogenicity
SLC27A5-related disorder, SLC27A5-related disorder
Health Risk
RS184994408
Conflicting classifications of pathogenicity
SLC27A5-related disorder, SLC27A5-related disorder
Health Risk
All Variants (27)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1162988139 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS141574728 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS143272701 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS146267408 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS146415600 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS146682651 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS147464959 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS148459550 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS149541658 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS149709084 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS150780205 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS184994408 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS200114980 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS200252519 | Health Risk | Conflicting classifications of pathogenicity | Uveal melanoma, Lung cancer, Familial cancer of breast |
| RS202054471 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS370326212 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS370902216 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS372436444 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS376013474 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS536826731 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS559467414 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS748584848 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS757127359 | Health Risk | Conflicting classifications of pathogenicity | SLC27A5-related disorder, SLC27A5-related disorder |
| RS769657523 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS886044091 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS887693979 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS956885811 | Health Risk | Conflicting classifications of pathogenicity | — |