SIN3A Chromosome 15

SIN3 transcription regulator family member A

97 variants 97 Health Risk

Upload your DNA to see your personal genotypes for variants in SIN3A.

What This Gene Does

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

Gene Info

Gene Group

"EMSY complex|SIN3 histone deacetylase complex subunits"

Locus Type

gene with protein product

Location

15q24.2

Ensembl

ENSG00000169375

Associated Conditions (9)

Inborn genetic diseases

SIN3A-related disorder

See cases

SIN3A-related intellectual disability syndrome due to a point mutation

Uterine corpus endometrial carcinoma

Neurodevelopmental disorder

SIN3A-related intellectual disability syndrome

Intellectual disability

Gastric cancer

Key Variants

RS142724257

Conflicting classifications of pathogenicity

Health Risk

RS200501190

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS201113909

Conflicting classifications of pathogenicity

Inborn genetic diseases, SIN3A-related disorder, Inborn genetic diseases

Health Risk

RS201414754

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS201853552

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS2141396034

Conflicting classifications of pathogenicity

See cases, See cases

Health Risk

RS2542982542

Conflicting classifications of pathogenicity

Health Risk

RS367989965

Conflicting classifications of pathogenicity

Health Risk

RS371395364

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS372433846

Conflicting classifications of pathogenicity

Health Risk

RS372626992

Conflicting classifications of pathogenicity

Health Risk

RS377177543

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

All Variants (97)

RSID	Category	Clinical Significance	Conditions
RS1555443682	Health Risk	Pathogenic	Inborn genetic diseases, Inborn genetic diseases
RS1555444879	Health Risk	Pathogenic	—
RS1567341422	Health Risk	Pathogenic	—
RS1567368243	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS1595897112	Health Risk	Pathogenic	—
RS1595907762	Health Risk	Pathogenic	—
RS2073161466	Health Risk	Pathogenic	Inborn genetic diseases, Inborn genetic diseases
RS2073271481	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2073399686	Health Risk	Pathogenic	Inborn genetic diseases, Inborn genetic diseases
RS2073599549	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2073603561	Health Risk	Pathogenic	—
RS2073604192	Health Risk	Pathogenic	—
RS2073858956	Health Risk	Pathogenic	Inborn genetic diseases, Inborn genetic diseases
RS2141425807	Health Risk	Pathogenic	See cases, See cases
RS2141487525	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2141540743	Health Risk	Pathogenic	—
RS2141540759	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2141571783	Health Risk	Pathogenic	—
RS2542629795	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2542629940	Health Risk	Pathogenic	—
RS2542638826	Health Risk	Pathogenic	—
RS2542638910	Health Risk	Pathogenic	—
RS2542665267	Health Risk	Pathogenic	Inborn genetic diseases, Inborn genetic diseases
RS2542681599	Health Risk	Pathogenic	—
RS2542682219	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2542689886	Health Risk	Pathogenic	—
RS2542690105	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2542787952	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2542997297	Health Risk	Pathogenic	Inborn genetic diseases, Inborn genetic diseases
RS2542998133	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2543016839	Health Risk	Pathogenic	Inborn genetic diseases, SIN3A-related intellectual disability syndrome due to a point mutation, Inborn genetic diseases
RS2543035478	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2543061332	Health Risk	Pathogenic	Inborn genetic diseases, Inborn genetic diseases
RS2543076155	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS757034687	Health Risk	Pathogenic	—
RS879255618	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS879255619	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS879255620	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS879255621	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS971198723	Health Risk	Pathogenic	SIN3A-related intellectual disability syndrome, SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome
RS1444395453	Health Risk	Pathogenic/Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related disorder, Intellectual disability
RS1555443581	Health Risk	Pathogenic/Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS1555444885	Health Risk	Pathogenic/Likely pathogenic	Inborn genetic diseases, SIN3A-related intellectual disability syndrome, Inborn genetic diseases
RS2141424841	Health Risk	Pathogenic/Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS2141426359	Health Risk	Pathogenic/Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation
RS778623853	Health Risk	Pathogenic/Likely pathogenic	—
RS886037847	Health Risk	Pathogenic/Likely pathogenic	SIN3A-related intellectual disability syndrome due to a point mutation, SIN3A-related intellectual disability syndrome due to a point mutation

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