SCUBE2 Chromosome 11
Signal peptide, CUB domain and EGF like domain containing 2
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What This Gene Does
Predicted to enable calcium ion binding activity; hedgehog family protein binding activity; and lipid binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; positive regulation of chondrocyte proliferation; and positive regulation of osteoblast differentiation. Predicted to be located in extracellular region. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Gene Info
Gene Group
MicroRNA protein coding host genes
Locus Type
gene with protein product
Location
11p15.4
Ensembl
ENSG00000175356
Associated Conditions (1)
Cerebral arteriovenous malformation
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1555238867 | Health Risk | Likely pathogenic | Cerebral arteriovenous malformation, Cerebral arteriovenous malformation |