RUFY4 Chromosome 2

RUN and FYVE domain containing 4

1 variant 1 Health Risk

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What This Gene Does

Enables phosphatidylinositol-3-phosphate binding activity. Involved in autophagosome assembly; cellular response to interleukin-4; and positive regulation of macroautophagy. Located in autophagosome. [provided by Alliance of Genome Resources, Apr 2025]

Gene Info

Gene Group

Zinc fingers FYVE-type

Locus Type

gene with protein product

Location

2q35

Ensembl

ENSG00000188282

Key Variants

RS55688870

Conflicting classifications of pathogenicity

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS55688870	Health Risk	Conflicting classifications of pathogenicity	—