PLK2 Chromosome 5

Polo like kinase 2

1 variant 1 Health Risk

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What This Gene Does

The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Info

Gene Group

Polo like kinase family

Locus Type

gene with protein product

Location

5q11.2

Ensembl

ENSG00000145632

Associated Conditions (1)

Hereditary breast ovarian cancer syndrome

Key Variants

RS772701630

Pathogenic

Hereditary breast ovarian cancer syndrome, Hereditary breast ovarian cancer syndrome

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS772701630	Health Risk	Pathogenic	Hereditary breast ovarian cancer syndrome, Hereditary breast ovarian cancer syndrome