PDLIM4 Chromosome 5

PDZ and LIM domain 4

1 variant 1 Health Risk

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What This Gene Does

Enables alpha-actinin binding activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in actin cytoskeleton organization. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and stress fiber. Part of filamentous actin. Implicated in osteoporosis. [provided by Alliance of Genome Resources, Jul 2025]

Gene Info

Gene Group

"LIM domain containing|PDZ domain containing"

Locus Type

gene with protein product

Location

5q31.1

Ensembl

ENSG00000131435

Associated Conditions (1)

BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15

Key Variants

RS453602

risk factor

BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15, BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS453602	Health Risk	risk factor	BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15, BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 15