PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1966842247 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1966967065 | Health Risk | Likely pathogenic | Malignant tumor of breast, Gastric cancer, Malignant tumor of breast |
| RS1967098495 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS202151522 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2142250624 | Health Risk | Likely pathogenic | Malignant tumor of breast, Malignant tumor of breast |
| RS2142251364 | Health Risk | Likely pathogenic | Malignant tumor of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |
| RS2142253658 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142254289 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142271053 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2142271759 | Health Risk | Likely pathogenic | Lynch syndrome 1, Lynch syndrome 1 |
| RS2142299058 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142300348 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142325910 | Health Risk | Likely pathogenic | Pancreatic cancer, susceptibility to, 3 |
| RS2142326815 | Health Risk | Likely pathogenic | Breast carcinoma, Breast carcinoma |
| RS2142334166 | Health Risk | Likely pathogenic | — |
| RS2142380442 | Health Risk | Likely pathogenic | — |
| RS2142417535 | Health Risk | Likely pathogenic | Breast carcinoma, Breast carcinoma |
| RS2142425187 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142444537 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506196328 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506196596 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506197497 | Health Risk | Likely pathogenic | Breast-ovarian cancer, familial, susceptibility to |
| RS2506215046 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506215712 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506219319 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506219403 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506264238 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506264814 | Health Risk | Likely pathogenic | — |
| RS2506265634 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506267514 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506337371 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506348014 | Health Risk | Likely pathogenic | Malignant tumor of breast, Malignant tumor of breast |
| RS2506349149 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506352068 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506395226 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506395256 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506401864 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506401937 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506410860 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506430834 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506433921 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506436018 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506440178 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506487811 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506494280 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506495427 | Health Risk | Likely pathogenic | Hereditary breast ovarian cancer syndrome, Hereditary breast ovarian cancer syndrome |
| RS2506506514 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506518424 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506534790 | Health Risk | Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506568316 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |