ORC6 Chromosome 16
Origin recognition complex subunit 6
Upload your DNA to see your personal genotypes for variants in ORC6.
What This Gene Does
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
Gene Info
Gene Group
Origin recognition complex
Locus Type
gene with protein product
Location
16q11.2
Ensembl
ENSG00000091651
Associated Conditions (6)
Meier-Gorlin syndrome 3
ORC6-related disorder
Inborn genetic diseases
Uterine corpus endometrial carcinoma
Gastric cancer
Papillary renal cell carcinoma type 1
Key Variants
RS138213159
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3
Health Risk
RS146795505
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 3, ORC6-related disorder, Meier-Gorlin syndrome 3
Health Risk
RS200089121
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 3, Inborn genetic diseases, Meier-Gorlin syndrome 3
Health Risk
RS572314014
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 3, Uterine corpus endometrial carcinoma, Gastric cancer
Health Risk
RS74999515
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3
Health Risk
RS758376049
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3
Health Risk
RS797045853
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3
Health Risk
RS2548892306
Likely pathogenic
Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3
Health Risk
RS748927298
Likely pathogenic
Health Risk
RS1279789023
Pathogenic
Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3
Health Risk
RS1476968223
Pathogenic
Health Risk
RS1966509824
Pathogenic
Health Risk
All Variants (19)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS138213159 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS146795505 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 3, ORC6-related disorder, Meier-Gorlin syndrome 3 |
| RS200089121 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 3, Inborn genetic diseases, Meier-Gorlin syndrome 3 |
| RS572314014 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 3, Uterine corpus endometrial carcinoma, Gastric cancer |
| RS74999515 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS758376049 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS797045853 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS2548892306 | Health Risk | Likely pathogenic | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS748927298 | Health Risk | Likely pathogenic | — |
| RS1279789023 | Health Risk | Pathogenic | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS1476968223 | Health Risk | Pathogenic | — |
| RS1966509824 | Health Risk | Pathogenic | — |
| RS2143010039 | Health Risk | Pathogenic | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS2548891307 | Health Risk | Pathogenic | — |
| RS387906969 | Health Risk | Pathogenic | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS777153067 | Health Risk | Pathogenic | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS786205258 | Health Risk | Pathogenic | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS879255692 | Health Risk | Pathogenic | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |
| RS35441257 | Health Risk | Pathogenic/Likely pathogenic | Meier-Gorlin syndrome 3, Meier-Gorlin syndrome 3 |