MRC1 Chromosome 10

Mannose receptor C-type 1
1 variant 1 Health Risk

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What This Gene Does
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
Gene Info
Gene Group
"CD molecules|Scavenger receptors|C-type lectin domain containing|MicroRNA protein coding host genes"
Locus Type
gene with protein product
Location
10p12.33
Ensembl
ENSG00000260314
Associated Conditions (4)
Susceptibility to leprosy and multibacillary leprosy
Leprosy
susceptibility to
1
Key Variants
RS606231248
Uncertain risk allele; risk factor
Susceptibility to leprosy and multibacillary leprosy, Leprosy, susceptibility to
Health Risk
All Variants (1)
RSID Category Clinical Significance Conditions
RS606231248 Health Risk Uncertain risk allele; risk factor Susceptibility to leprosy and multibacillary leprosy, Leprosy, susceptibility to
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