MEN1 Chromosome 11
Menin 1
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What This Gene Does
This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019]
Associated Conditions (27)
Hereditary cancer-predisposing syndrome
Multiple endocrine neoplasia
type 1
MEN1-related disorder
Hereditary cancer
Hyperparathyroidism
Ovarian cancer
Endocrine neoplasia
Primary hyperparathyroidism
Malignant tumor of esophagus
Malignant tumor of urinary bladder
Somatotroph adenoma
Uterine corpus endometrial carcinoma
Colon adenocarcinoma
Hereditary breast ovarian cancer syndrome
6 conditions
Angiofibroma
somatic
Adrenocortical adenoma
Ovarian serous cystadenocarcinoma
+7 more conditions
Key Variants
RS1018289242
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1
Health Risk
RS1043531053
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1
Health Risk
RS1046929915
Conflicting classifications of pathogenicity
Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome
Health Risk
RS104894268
Conflicting classifications of pathogenicity
Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia
Health Risk
RS1057521847
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1
Health Risk
RS1060499971
Conflicting classifications of pathogenicity
Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia
Health Risk
RS1060499972
Conflicting classifications of pathogenicity
Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499975
Conflicting classifications of pathogenicity
Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499977
Conflicting classifications of pathogenicity
Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499982
Conflicting classifications of pathogenicity
Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499983
Conflicting classifications of pathogenicity
Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499988
Conflicting classifications of pathogenicity
Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome
Health Risk
All Variants (703)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1592646765 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome |
| RS1592647281 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS1592649108 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome |
| RS1592649598 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS1592660695 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS1941501393 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1941522995 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS1941550135 | Health Risk | Likely pathogenic | — |
| RS1941604532 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS1941615895 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS1941726727 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS1941862506 | Health Risk | Likely pathogenic | — |
| RS1942013583 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome |
| RS2071312 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2136078405 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2136079024 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2136110242 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2136130282 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2136132542 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2136148225 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2136148788 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2136154163 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2136154828 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2136178004 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1 |
| RS2136178143 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2136192730 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2136194342 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2497104394 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2497106547 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2497106696 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome |
| RS2497107321 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2497127636 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2497143876 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2497145649 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2497161656 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2497171722 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2497174269 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2497202890 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2497203524 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2497218675 | Health Risk | Likely pathogenic | — |
| RS2497226943 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS2497255432 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS386134246 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS386134254 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS386134255 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS386134258 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS386134261 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS753942853 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Multiple endocrine neoplasia |
| RS757179911 | Health Risk | Likely pathogenic | Multiple endocrine neoplasia, type 1, Hereditary cancer-predisposing syndrome |
| RS775922507 | Health Risk | Likely pathogenic | Hereditary cancer-predisposing syndrome, Multiple endocrine neoplasia, type 1 |