MAP3K15 Chromosome X
Mitogen-activated protein kinase kinase kinase 15
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What This Gene Does
The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]
Gene Info
Gene Group
Mitogen-activated protein kinase kinase kinases
Locus Type
gene with protein product
Location
Xp22.12
Ensembl
ENSG00000180815
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS145675672 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS373969675 | Health Risk | Conflicting classifications of pathogenicity | — |