MAP3K11 Chromosome 11
Mitogen-activated protein kinase kinase kinase 11
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What This Gene Does
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"Mitogen-activated protein kinase kinase kinases|Mixed lineage kinase family"
Locus Type
gene with protein product
Location
11q13.1
Ensembl
ENSG00000173327
Associated Conditions (1)
Moyamoya angiopathy
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS746476599 | Health Risk | Likely pathogenic | Moyamoya angiopathy, Moyamoya angiopathy |