LYRM4 Chromosome 6

LYR motif containing 4

1 variant 1 Health Risk

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What This Gene Does

The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]

Gene Info

Gene Group

"LYR motif containing|MicroRNA protein coding host genes|Mitochondrial iron-sulfur assembly components"

Locus Type

gene with protein product

Location

6p25.1

Ensembl

ENSG00000214113

Associated Conditions (1)

Combined oxidative phosphorylation deficiency 19

Key Variants

RS587777218

Pathogenic

Combined oxidative phosphorylation deficiency 19, Combined oxidative phosphorylation deficiency 19

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS587777218	Health Risk	Pathogenic	Combined oxidative phosphorylation deficiency 19, Combined oxidative phosphorylation deficiency 19