KLF6 Chromosome 10
KLF transcription factor 6
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What This Gene Does
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]
Gene Info
Gene Group
"Zinc fingers C2H2-type|KLF transcription factors"
Locus Type
gene with protein product
Location
10p15.2
Ensembl
ENSG00000067082
Associated Conditions (3)
Prostate cancer
somatic
Gastric cancer
Key Variants
RS121909139
Pathogenic
Prostate cancer, somatic, Prostate cancer
Health Risk
RS121909140
Pathogenic
Prostate cancer, somatic, Prostate cancer
Health Risk
RS121909141
Pathogenic
Prostate cancer, somatic, Prostate cancer
Health Risk
RS121909142
Pathogenic
Prostate cancer, somatic, Prostate cancer
Health Risk
RS121909143
Pathogenic
Prostate cancer, somatic, Prostate cancer
Health Risk
RS121909144
Pathogenic
Gastric cancer, Gastric cancer
Health Risk
All Variants (6)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS121909139 | Health Risk | Pathogenic | Prostate cancer, somatic, Prostate cancer |
| RS121909140 | Health Risk | Pathogenic | Prostate cancer, somatic, Prostate cancer |
| RS121909141 | Health Risk | Pathogenic | Prostate cancer, somatic, Prostate cancer |
| RS121909142 | Health Risk | Pathogenic | Prostate cancer, somatic, Prostate cancer |
| RS121909143 | Health Risk | Pathogenic | Prostate cancer, somatic, Prostate cancer |
| RS121909144 | Health Risk | Pathogenic | Gastric cancer, Gastric cancer |