KAT2A Chromosome 17
Lysine acetyltransferase 2A
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What This Gene Does
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
Gene Info
Gene Group
"Lysine acetyltransferases|ATAC complex|SAGA complex|GCN5 related N-acetyltransferases|Bromodomain containing"
Locus Type
gene with protein product
Location
17q21.2
Ensembl
ENSG00000108773
Associated Conditions (1)
See cases
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2544066740 | Health Risk | Likely pathogenic | See cases, See cases |