IRF7 Chromosome 11
Interferon regulatory factor 7
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What This Gene Does
This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]
Gene Info
Gene Group
Interferon regulatory factors
Locus Type
gene with protein product
Location
11p15.5
Ensembl
ENSG00000185507
Associated Conditions (2)
Immunodeficiency 39
IRF7-related disorder
Key Variants
RS1156894268
Conflicting classifications of pathogenicity
Immunodeficiency 39, Immunodeficiency 39
Health Risk
RS201379782
Conflicting classifications of pathogenicity
Immunodeficiency 39, IRF7-related disorder, Immunodeficiency 39
Health Risk
RS759040714
Conflicting classifications of pathogenicity
Immunodeficiency 39, Immunodeficiency 39
Health Risk
RS772836644
Conflicting classifications of pathogenicity
Immunodeficiency 39, Immunodeficiency 39
Health Risk
RS777401747
Conflicting classifications of pathogenicity
Immunodeficiency 39, Immunodeficiency 39
Health Risk
RS375323253
risk factor
Immunodeficiency 39, Immunodeficiency 39
Health Risk
All Variants (6)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1156894268 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency 39, Immunodeficiency 39 |
| RS201379782 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency 39, IRF7-related disorder, Immunodeficiency 39 |
| RS759040714 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency 39, Immunodeficiency 39 |
| RS772836644 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency 39, Immunodeficiency 39 |
| RS777401747 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency 39, Immunodeficiency 39 |
| RS375323253 | Health Risk | risk factor | Immunodeficiency 39, Immunodeficiency 39 |