IQGAP3 Chromosome 1
IQ motif containing GTPase activating protein 3
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What This Gene Does
Enables calmodulin binding activity and myosin VI light chain binding activity. Predicted to be involved in mitotic actomyosin contractile ring assembly actin filament organization. Predicted to act upstream of or within several processes, including G1/S transition of mitotic cell cycle; intracellular signaling cassette; and regulation of macromolecule metabolic process. Predicted to be located in cytosol. Predicted to be active in cell cortex. [provided by Alliance of Genome Resources, Apr 2025]
Gene Info
Gene Group
IQ motif containing GTPase activating protein family
Locus Type
gene with protein product
Location
1q22
Ensembl
ENSG00000183856
Associated Conditions (1)
Motor and sensory neuropathy
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1571320137 | Health Risk | Likely pathogenic | Motor and sensory neuropathy, Motor and sensory neuropathy |