ING1 Chromosome 13
Inhibitor of growth family member 1
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What This Gene Does
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
PHD finger proteins
Locus Type
gene with protein product
Location
13q34
Ensembl
ENSG00000153487
Associated Conditions (1)
Squamous cell carcinoma of the head and neck
Key Variants
RS121909250
Pathogenic
Squamous cell carcinoma of the head and neck, Squamous cell carcinoma of the head and neck
Health Risk
RS121909251
Pathogenic
Squamous cell carcinoma of the head and neck, Squamous cell carcinoma of the head and neck
Health Risk
RS121909252
Pathogenic
Squamous cell carcinoma of the head and neck, Squamous cell carcinoma of the head and neck
Health Risk
All Variants (3)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS121909250 | Health Risk | Pathogenic | Squamous cell carcinoma of the head and neck, Squamous cell carcinoma of the head and neck |
| RS121909251 | Health Risk | Pathogenic | Squamous cell carcinoma of the head and neck, Squamous cell carcinoma of the head and neck |
| RS121909252 | Health Risk | Pathogenic | Squamous cell carcinoma of the head and neck, Squamous cell carcinoma of the head and neck |