IL37 Chromosome 2
Interleukin 37
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What This Gene Does
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Interleukins
Locus Type
gene with protein product
Location
2q14.1
Ensembl
ENSG00000125571
Associated Conditions (1)
Inflammatory bowel disease
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS765216544 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS750833867 | Health Risk | Pathogenic | Inflammatory bowel disease, Inflammatory bowel disease |