ICAM4 Chromosome 19
Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Upload your DNA to see your personal genotypes for variants in ICAM4.
What This Gene Does
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"Blood group antigens|CD molecules|Immunoglobulin like domain containing|Ig-like cell adhesion molecule family"
Locus Type
gene with protein product
Location
19p13.2
Ensembl
ENSG00000105371
Associated Conditions (1)
Landsteiner-Wiener phenotype
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS77493670 | Trait | Affects | Landsteiner-Wiener phenotype, Landsteiner-Wiener phenotype |
| RS778248852 | Trait | Affects | Landsteiner-Wiener phenotype, Landsteiner-Wiener phenotype |