HROB Chromosome 17

Homologous recombination factor with OB-fold

1 variant 1 Health Risk

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What This Gene Does

Predicted to enable single-stranded DNA binding activity. Involved in DNA synthesis involved in DNA repair and interstrand cross-link repair. Located in site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]

Associated Conditions (2)

Premature ovarian insufficiency

Ovarian dysgenesis 11

Key Variants

RS762836620

Pathogenic/Likely pathogenic

Premature ovarian insufficiency, Ovarian dysgenesis 11, Premature ovarian insufficiency

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS762836620	Health Risk	Pathogenic/Likely pathogenic	Premature ovarian insufficiency, Ovarian dysgenesis 11, Premature ovarian insufficiency