HDAC7 Chromosome 12
Histone deacetylase 7
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What This Gene Does
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Histone deacetylases, class IIA
Locus Type
gene with protein product
Location
12q13.11
Ensembl
ENSG00000061273
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS144718030 | Health Risk | Conflicting classifications of pathogenicity | — |