HCRT Chromosome 17
Hypocretin neuropeptide precursor
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What This Gene Does
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
Gene Info
Gene Group
Neuropeptides
Locus Type
gene with protein product
Location
17q21.2
Ensembl
ENSG00000161610
Associated Conditions (1)
Narcolepsy 1
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS104894574 | Health Risk | Pathogenic | Narcolepsy 1, Narcolepsy 1 |