GSE1 Chromosome 16

Gse1 coiled-coil protein

1 variant 1 Health Risk

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What This Gene Does

This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast cancer and enhanced expression of the encoded protein has been observed in breast cancer patients. [provided by RefSeq, May 2017]

Associated Conditions (6)

Uterine corpus endometrial carcinoma

Acute myeloid leukemia

Malignant tumor of urinary bladder

Adrenocortical carcinoma

hereditary

Thymoma

Key Variants

RS151194801

Conflicting classifications of pathogenicity

Uterine corpus endometrial carcinoma, Acute myeloid leukemia, Malignant tumor of urinary bladder

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS151194801	Health Risk	Conflicting classifications of pathogenicity	Uterine corpus endometrial carcinoma, Acute myeloid leukemia, Malignant tumor of urinary bladder