GPR161 Chromosome 1
G protein-coupled receptor 161
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What This Gene Does
The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]
Gene Info
Gene Group
G protein-coupled receptors, Class A orphans
Locus Type
gene with protein product
Location
1q24.2
Ensembl
ENSG00000143147
Associated Conditions (2)
Pituitary stalk interruption syndrome
Medulloblastoma
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS200635937 | Health Risk | Conflicting classifications of pathogenicity | Pituitary stalk interruption syndrome, Medulloblastoma, Pituitary stalk interruption syndrome |
| RS147891461 | Health Risk | Pathogenic | Medulloblastoma, Medulloblastoma |