GDAP2 Chromosome 1

Ganglioside induced differentiation associated protein 2
7 variants 7 Health Risk

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What This Gene Does
Predicted to act upstream of or within response to retinoic acid. Located in lysosomal membrane. Implicated in autosomal recessive spinocerebellar ataxia 27. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
"BCH domain containing |Macro domain containing|CRAL-TRIO lipid binding domain containing"
Locus Type
gene with protein product
Location
1p12
Ensembl
ENSG00000196505
Associated Conditions (3)
Spinocerebellar ataxia
autosomal recessive 27
GDAP2-related disorder
Key Variants
All Variants (7)
RSID Category Clinical Significance Conditions
RS141678357 Health Risk Likely pathogenic
RS1648861791 Health Risk Likely pathogenic Spinocerebellar ataxia, autosomal recessive 27, Spinocerebellar ataxia
RS747457022 Health Risk Likely pathogenic GDAP2-related disorder, GDAP2-related disorder
RS1557794465 Health Risk Pathogenic Spinocerebellar ataxia, autosomal recessive 27, Spinocerebellar ataxia
RS372395282 Health Risk Pathogenic
RS547792505 Health Risk Pathogenic Spinocerebellar ataxia, autosomal recessive 27, Spinocerebellar ataxia
RS752352896 Health Risk Pathogenic Spinocerebellar ataxia, autosomal recessive 27, Spinocerebellar ataxia
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