FANCC Chromosome 9

FA complementation group C
371 variants 371 Health Risk

Upload your DNA to see your personal genotypes for variants in FANCC.

What This Gene Does
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"FA complementation groups|FA core complex"
Locus Type
gene with protein product
Location
9q22.32
Ensembl
ENSG00000158169
Associated Conditions (16)
Fanconi anemia complementation group C
Fanconi anemia
Hereditary cancer-predisposing syndrome
FANCC-related disorder
Ovarian cancer
Malignant tumor of breast
Hereditary cancer
Fanconi anemia complementation group A
Hereditary breast ovarian cancer syndrome
Sarcoma
Gastric cancer
Ovarian serous cystadenocarcinoma
Uterine carcinosarcoma
Familial ovarian cancer
Melanoma
Carcinoma of colon
Key Variants
RS1057516298
Conflicting classifications of pathogenicity
Fanconi anemia complementation group C, Fanconi anemia, Hereditary cancer-predisposing syndrome
Health Risk
RS1057521714
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
Health Risk
RS1057522128
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome
Health Risk
RS1064793109
Conflicting classifications of pathogenicity
FANCC-related disorder, Hereditary cancer-predisposing syndrome, FANCC-related disorder
Health Risk
RS1064793110
Conflicting classifications of pathogenicity
Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
Health Risk
RS1064793625
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome
Health Risk
RS1064793837
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia
Health Risk
RS1064794691
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
Health Risk
RS1197938479
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia
Health Risk
RS1224625808
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
Health Risk
RS1228873579
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia
Health Risk
RS1228886763
Conflicting classifications of pathogenicity
Fanconi anemia complementation group C, Fanconi anemia, Fanconi anemia complementation group C
Health Risk
All Variants (371)
RSID Category Clinical Significance Conditions
RS2540886717 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2540948713 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2540949591 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2541136426 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia
RS2541139869 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2541176302 Health Risk Likely pathogenic —
RS2541398976 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2541401806 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2541695491 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2541701286 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2541701808 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2541950774 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2542755054 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2542756207 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2542842484 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2542842989 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2542844105 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2542859477 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2542863248 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia
RS370510954 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome
RS769998628 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS863224441 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia, Fanconi anemia complementation group C
RS876661231 Health Risk Likely pathogenic —
RS1035139114 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Fanconi anemia complementation group C
RS104886456 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Hereditary cancer-predisposing syndrome
RS104886459 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Hereditary cancer-predisposing syndrome
RS1057516488 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Fanconi anemia complementation group C
RS1057517131 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Fanconi anemia complementation group C
RS1057517203 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Fanconi anemia complementation group C
RS1057517219 Health Risk Pathogenic Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome, Fanconi anemia
RS1060499606 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1064793405 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C, Fanconi anemia
RS1195346607 Health Risk Pathogenic Fanconi anemia, Fanconi anemia
RS121917783 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Hereditary cancer-predisposing syndrome
RS121917784 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Hereditary cancer-predisposing syndrome
RS121917785 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1380999715 Health Risk Pathogenic Fanconi anemia, Fanconi anemia
RS1410356625 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Hereditary cancer-predisposing syndrome
RS1425473449 Health Risk Pathogenic Fanconi anemia, Fanconi anemia
RS1554827159 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Fanconi anemia complementation group C
RS1554829415 Health Risk Pathogenic Fanconi anemia, Fanconi anemia
RS1554829561 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia, Fanconi anemia complementation group C
RS1564667865 Health Risk Pathogenic Fanconi anemia, Fanconi anemia
RS1564720605 Health Risk Pathogenic Fanconi anemia, Fanconi anemia
RS1588134571 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome
RS1588220764 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1825652623 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1825714345 Health Risk Pathogenic Fanconi anemia, Fanconi anemia
RS1830058898 Health Risk Pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1831171802 Health Risk Pathogenic Fanconi anemia, Fanconi anemia
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