DNHD1 Chromosome 11

Dynein heavy chain domain 1

52 variants 52 Health Risk

Upload your DNA to see your personal genotypes for variants in DNHD1.

What This Gene Does

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in sperm flagellum assembly. Located in sperm flagellum. Implicated in spermatogenic failure 65. [provided by Alliance of Genome Resources, Jul 2025]

Associated Conditions (5)

DNHD1-related disorder

Spermatogenic failure 65

Ovarian serous cystadenocarcinoma

Male infertility with spermatogenesis disorder

See cases

Key Variants

RS12574381

Conflicting classifications of pathogenicity

Health Risk

RS138517528

Conflicting classifications of pathogenicity

Health Risk

RS142389357

Conflicting classifications of pathogenicity

Health Risk

RS143422606

Conflicting classifications of pathogenicity

Health Risk

RS149962461

Conflicting classifications of pathogenicity

Health Risk

RS180925806

Conflicting classifications of pathogenicity

Ovarian serous cystadenocarcinoma, Ovarian serous cystadenocarcinoma

Health Risk

RS189772244

Conflicting classifications of pathogenicity

Health Risk

RS375892626

Conflicting classifications of pathogenicity

Health Risk

RS73407163

Conflicting classifications of pathogenicity

Health Risk

RS750156561

Conflicting classifications of pathogenicity

Male infertility with spermatogenesis disorder, Male infertility with spermatogenesis disorder

Health Risk

RS751352585

Conflicting classifications of pathogenicity

Health Risk

RS759052984

Conflicting classifications of pathogenicity

Male infertility with spermatogenesis disorder, DNHD1-related disorder, Male infertility with spermatogenesis disorder

Health Risk

All Variants (52)

RSID	Category	Clinical Significance	Conditions
RS12574381	Health Risk	Conflicting classifications of pathogenicity	DNHD1-related disorder, Spermatogenic failure 65, DNHD1-related disorder
RS138517528	Health Risk	Conflicting classifications of pathogenicity	DNHD1-related disorder, DNHD1-related disorder
RS142389357	Health Risk	Conflicting classifications of pathogenicity	—
RS143422606	Health Risk	Conflicting classifications of pathogenicity	DNHD1-related disorder, DNHD1-related disorder
RS149962461	Health Risk	Conflicting classifications of pathogenicity	—
RS180925806	Health Risk	Conflicting classifications of pathogenicity	Ovarian serous cystadenocarcinoma, Ovarian serous cystadenocarcinoma
RS189772244	Health Risk	Conflicting classifications of pathogenicity	—
RS375892626	Health Risk	Conflicting classifications of pathogenicity	—
RS73407163	Health Risk	Conflicting classifications of pathogenicity	DNHD1-related disorder, DNHD1-related disorder
RS750156561	Health Risk	Conflicting classifications of pathogenicity	Male infertility with spermatogenesis disorder, Male infertility with spermatogenesis disorder
RS751352585	Health Risk	Conflicting classifications of pathogenicity	—
RS759052984	Health Risk	Conflicting classifications of pathogenicity	Male infertility with spermatogenesis disorder, DNHD1-related disorder, Male infertility with spermatogenesis disorder
RS761155698	Health Risk	Conflicting classifications of pathogenicity	DNHD1-related disorder, DNHD1-related disorder
RS763743788	Health Risk	Conflicting classifications of pathogenicity	See cases, See cases
RS767337781	Health Risk	Conflicting classifications of pathogenicity	DNHD1-related disorder, DNHD1-related disorder
RS929548279	Health Risk	Conflicting classifications of pathogenicity	DNHD1-related disorder, DNHD1-related disorder
RS1003144542	Health Risk	Likely pathogenic	Spermatogenic failure 65, Spermatogenic failure 65
RS1035842147	Health Risk	Likely pathogenic	Spermatogenic failure 65, Spermatogenic failure 65
RS1244142295	Health Risk	Likely pathogenic	—
RS1386324073	Health Risk	Likely pathogenic	Spermatogenic failure 65, Spermatogenic failure 65
RS199752008	Health Risk	Likely pathogenic	Spermatogenic failure 65, Spermatogenic failure 65
RS2134462764	Health Risk	Likely pathogenic	Spermatogenic failure 65, Spermatogenic failure 65
RS369544858	Health Risk	Likely pathogenic	Spermatogenic failure 65, Spermatogenic failure 65
RS377539525	Health Risk	Likely pathogenic	—
RS762515987	Health Risk	Likely pathogenic	Spermatogenic failure 65, Spermatogenic failure 65
RS764070280	Health Risk	Likely pathogenic	Spermatogenic failure 65, Spermatogenic failure 65
RS780240951	Health Risk	Likely pathogenic	—
RS899201476	Health Risk	Likely pathogenic	—
RS1012468951	Health Risk	Pathogenic	—
RS1056169167	Health Risk	Pathogenic	—
RS1214230970	Health Risk	Pathogenic	—
RS1419526899	Health Risk	Pathogenic	—
RS1424365656	Health Risk	Pathogenic	—
RS1853238476	Health Risk	Pathogenic	—
RS187626415	Health Risk	Pathogenic	Spermatogenic failure 65, Spermatogenic failure 65
RS2494007936	Health Risk	Pathogenic	—
RS2494057078	Health Risk	Pathogenic	—
RS2494071871	Health Risk	Pathogenic	—
RS2494075356	Health Risk	Pathogenic	—
RS368113841	Health Risk	Pathogenic	—
RS544185938	Health Risk	Pathogenic	—
RS553960466	Health Risk	Pathogenic	—
RS567990186	Health Risk	Pathogenic	—
RS754601076	Health Risk	Pathogenic	—
RS756886777	Health Risk	Pathogenic	Spermatogenic failure 65, Spermatogenic failure 65
RS757652435	Health Risk	Pathogenic	—
RS767629627	Health Risk	Pathogenic	—
RS780027666	Health Risk	Pathogenic	—
RS942394169	Health Risk	Pathogenic	—
RS201118703	Health Risk	Pathogenic/Likely pathogenic	Spermatogenic failure 65, Spermatogenic failure 65

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